Brains for Dementia Research has supported hundreds of research studies since we began in 2007. You can see some recent publications here that have benefitted from Brains for Dementia Research support.
Download the full list of publications that have benefitted from Brains for Dementia Research.
2021
Yamamoto, Y; Hase, Y; Ihara, M; Khundakar, A; Roeber, S; Duering, M; Kalaria, RN. Neuronal densities and vascular pathology in the hippocampal formation in CADASIL. NEUROBIOLOGY OF AGING, 10.1016/j.neurobiolaging.2020.09.016
Attems, J; Toledo, JB; Walker, L; Gelpi, E; Gentleman, S; Halliday, G; Hortobagyi, T; Jellinger, K; Kovacs, GG; Lee, EB; Love, S; McAleese, KE; Nelson, PT; Neumann, M; Parkkinen, L; Polvikoski, T; Sikorska, B; Smith, C; Grinberg, LT; Thal, DR; Trojanowski, JQ; McKeith, IG. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. ACTA NEUROPATHOLOGICA, 10.1007/s00401-020-02255-2
Feneberg, E; Charles, PD; Finelli, MJ; Scott, C; Kessler, BM; Fischer, R; Ansorge, O; Gray, E; Talbot, K; Turner, MR. Detection and quantification of novel C-terminal TDP-43 fragments in ALS-TDP. BRAIN PATHOLOGY, 10.1111/bpa.12923
Low, CYB; Lee, JH; Lim, FTW; Lee, CL; Ballard, C; Francis, PT; Lai, MKP; Tan, MGK, Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer’s disease and Lewy body dementias. BRAIN PATHOLOGY, 10.1111/bpa.12917
Erskine, D; Koss, D; Korolchuk, VI; Outeiro, TF; Attems, J; McKeith, I. Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders. ACTA NEUROPATHOLOGICA, 10.1007/s00401-021-02266-7
Walker, JM; Richardson, TE; Farrell, K; Iida, MA; Foong, C; Shang, P; Attems, J; Ayalon, G; Beach, TG; Bigio, EH; Budson, A; Cairns, NJ; Corrada, M; Cortes, E; Dickson, DW; Fischer, P; Flanagan, ME; Franklin, E; Gearing, M; Glass, J; Hansen, LA; Haroutunian, V; Hof, PR; Honig, L; Kawas, C; Keene, CD; Kofler, J; Kovacs, GG; Lee, EB; Lutz, MI; Mao, QW; Masliah, E; McKee, AC; McMillan, CT; Mesulam, MM; Murray, M; Nelson, PT; Perrin, R; Pham, T; Poon, W; Purohit, DP; Rissman, RA; Sakai, K; Sano, M; Schneider, JA; Stein, TD; Teich, AF; Trojanowski, JQ; Troncoso, JC; Vonsattel, JP; Weintraub, S; Wolk, DA; Woltjer, RL; Yamada, M; Yu, L; White, CL; Crary, JF. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 10.1093/jnen/nlaa153
Janssens, J; Hermans, B; Vandermeeren, M; Barale-Thomas, E; Borgers, M; Willems, R; Meulders, G; Wintmolders, C; Van den Bulck, D; Bottelbergs, A; Ver Donck, L; Larsen, P; Moechars, D; Edwards, W; Mercken, M; Van Broeck, B. Passive immunotherapy with a novel antibody against 3pE-modified A? demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice. NEUROBIOLOGY OF DISEASE, 10.1016/j.nbd.2021.105365
Lawingco, T; Chaudhury, S; Brookes, KJ; Guetta-Baranes, T; Guerreiro, R; Bras, J; Hardy, J; Francis, P; Thomas, A; Belbin, O; Morgan, K. Genetic variants in glutamate-, A beta-, and tau-related pathways determine polygenic risk for Alzheimer’s disease. NEUROBIOLOGY OF AGING, 10.1016/j.neurobiolaging.2020.11.009
Oliveira, FPM; Walker, Z; Walker, RWH; Attems, J; Castanheira, JC; Silva, A; Oliveira, C; Vaz, S; Silva, M; Costa, DC. I-123-FP-CIT SPECT in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease: a new quantitative analysis of autopsy confirmed cases. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 10.1136/jnnp-2020-324606
Robinson, AC; Davidson, YS; Roncaroli, F; Minshull, J; Tinkler, P; Horan, MA; Payton, A; Pendleton, N; Mann, DMA. Early changes in visuospatial episodic memory can help distinguish primary age-related tauopathy from Alzheimer’s disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 10.1111/nan.12726
Erskine, D; Attems, J. Insights into Lewy body disease from rare neurometabolic disorders. JOURNAL OF NEURAL TRANSMISSION, 10.1007/s00702-021-02355-7
Hammond, J; Maher, BA; Ahmed, IAM; Allsop, D . Variation in the concentration and regional distribution of magnetic nanoparticles in human brains, with and without Alzheimer’s disease, from the UK. SCIENTIFIC REPORTS, 10.1038/s41598-021-88725-3
McMurray, L; Macdonald, JA; Ramakrishnan, NK; Zhao, YY; Williamson, DW; Tietz, O; Zhou, XY; Kealey, S; Fagan, SG; Smolek, T; Cubinkova, V; Zilka, N; Spillantini, MG; Tolkovsky, AM; Goedert, M; Aigbirhio, FI. Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models. ACS CHEMICAL NEUROSCIENCE, 10.1021/acschemneuro.0c00790
Hu, YL; Fryatt, GL; Ghorbani, M; Obst, J; Menassa, DA; Martin-Estebane, M; Muntslag, TAO; Olmos-Alonso, A; Guerrero-Carrasco, M; Thomas, D; Cragg, MS; Gomez-Nicola, D. Replicative senescence dictates the emergence of disease-associated microglia and contributes to A beta pathology. CELL REPORTS, 10.1016/j.celrep.2021.109228
Smith, RG; Pishva, E; Shireby, G; Smith, AR; Roubroeks, JAY; Hannon, E; Wheildon, G; Mastroeni, D; Gasparoni, G; Riemenschneider, M; Giese, A; Sharp, AJ; Schalkwyk, L; Haroutunian, V; Viechtbauer, W; van den Hove, DLA; Weedon, M; Brokaw, D; Francis, PT; Thomas, AJ; Love, S; Morgan, K; Walter, J; Coleman, PD; Bennett, DA; De Jager, PL; Mill, J; Lunnon, K. A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex. NATURE COMMUNICATIONS, 10.1038/s41467-021-23243-4
Tanudjojo, B; Shaikh, SS; Fenyi, A; Bousset, L; Agarwal, D; Marsh, J; Zois, C; Heman-Ackah, S; Fischer, R; Sims, D; Melki, R; Tofaris, GK. Phenotypic manifestation of alpha-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons. NATURE COMMUNICATIONS, 10.1038/s41467-021-23682-z
Steg, LC; Shireby, GL; Imm, J; Davies, JP; Franklin, A; Flynn, R; Namboori, SC; Bhinge, A; Jeffries, AR; Burrage, J; Neilson, GWA; Walker, EM; Perfect, LW; Price, J; McAlonan, G; Srivastava, DP; Bray, NJ; Cope, EL; Jones, KM; Allen, ND; Pishva, E; Dempster, EL; Lunnon, K; Mill, J; Hannon, E. Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. MOLECULAR BRAIN, 10.1186/s13041-021-00810-w
Manzanza, ND; Sedlackova, L; Kalaria, RN. Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders. FRONTIERS IN AGING NEUROSCIENCE, 10.3389/fnagi.2021.690293