Brains for Dementia Research has supported hundreds of research studies since we began in 2007. You can see some recent publications here that have benefitted from Brains for Dementia Research support. You can download a full list of publications that have benefitted from Brains for Dementia Research here.

Chai, YL; Chong, JR; Weng, JJ; Howlett, D; Halsey, A; Lee, JH; Attems, J; Aarsland, D; Francis, PT; Chet, CP; Lai, MK. (2019) Lysosomal cathepsin D is upregulated in Alzheimer’s disease neocortex and may be a marker for neurofibrillary degeneration. BRAIN PATHOLOGY, 10.1111/bpa.12631

Hayhurst, H; Anagnostou, ME; Bogle, HJ; Grady, JP; Taylor, RW; Bindoff, LA; McFarland, R; Turnbull, DM; Lax, NZ. (2019) Dissecting the neuronal vulnerability underpinning Alpers’ syndrome: a clinical and neuropathological study. BRAIN PATHOLOGY, 10.1111/bpa.12640

Smith, AR; Smith, RG; Burrage, J; Troakes, C; Al-Sarraj, S; Kalaria, RN; Sloan, C; Robinson, AC; Mill, J; Lunnon, K. (2019) A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. NEUROBIOLOGY OF AGING, 10.1016/j.neurobiolaging.2018.09.024

Ashton, NJ; Leuzy, A; Lim, YM; Troakes, C; Hortobagyi, T; Hoglund, K; Aarsland, D; Lovestone, S; Scholl, M; Blennow, K; Zetterberg, H; Hye, A. (2019) Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 10.1186/s40478-018-0649-3

Harris, R; Miners, JS; Allen, S; Love, S. (2018) VEGFR1 and VEGFR2 in Alzheimer’s Disease. JOURNAL OF ALZHEIMERS DISEASE, 10.3233/JAD-170745

Chai, YL; Xing, HY; Chong, JR; Francis, PT; Ballard, CG; Chen, CP; Lai, MKP. (2018) Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer’s Disease. JOURNAL OF ALZHEIMERS DISEASE, 10.3233/JAD-170613

Condello, C; Lemmin, T; Stohr, J; Nick, M; Wu, Y; Maxwell, AM; Watts, JC; Caro, CD; Oehler, A; Keene, CD; Bird, TD; van Duinen, SG; Lannfelt, L; Ingelsson, M; Graff, C; Giles, K; DeGrado, WF; Prusiner, SB. (2018) Structural heterogeneity and intersubject variability of A beta in familial and sporadic Alzheimer’s disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 10.1073/pnas.1714966115

Bereczki, E; Branca, RM; Francis, PT; Pereira, JB; Baek, JH; Hortobagyi, T; Winblad, B; Ballard, C; Lehtio, J; Aarsland, D. (2018) Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach. BRAIN, 10.1093/brain/awx352

Evans, T; Kok, WL; Cowan, K; Hefford, M; Anichtchik, O. (2018)  Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients. BRAIN RESEARCH, 10.1016/j.brainres.2017.12.026

Miners, JS; Schulz, I; Love, S. Differing associations between Ab accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer’s disease. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,    10.1177/0271678X17690761

Erskine, D; Patterson, L; Alexandris, A; Hanson, PS; McKeith, IG; Attems, J; Morris, CM. (2018) Regional levels of physiological alpha-synuclein are directly associated with Lewy body pathology. ACTA NEUROPATHOLOGICA, 10.1007/s00401-017-1787-6

Davidson, YS; Robinson, AC; Rollinson, S; Pickering-Brown, S; Xiao, SX; Robertson, J; Mann, DMA. (2018) Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies. AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 10.1080/21678421.2017.1359304

Taipa, R; Ferreira, V; Brochado, P; Robinson, A; Reis, I; Marques, F; Mann, DM; Melo-Pires, M; Sousa, N. (2018) Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 10.1111/nan.12445

Hase, Y; Horsburgh, K; Ihara, M; Kalaria, RN. (2018) White matter degeneration in vascular and other ageing-related dementias. JOURNAL OF NEUROCHEMISTRY, 10.1111/jnc.14271

Sassi, C; Nalls, MA; Ridge, PG; Gibbs, JR; Lupton, MK; Troakes, C; Lunnon, K; Al-Sarraj, S; Brown, KS; Medway, C; Lord, J; Turton, J; Bras, J; Blumenau, S; Thielke, M; Josties, C; Freyer, D; Dietrich, A; Hammer, M; Baier, M; Dirnagl, U; Morgan, K; Powell, JF; Kauwe, JS; Cruchaga, C; Goate, AM; Singleton, AB; Guerreiro, R; Hodges, A; Hardy, J. (2018) Mendelian adult-onset leukodystrophy genes in Alzheimer’s disease: critical influence of CSF1R and NOTCH3. NEUROBIOLOGY OF AGING, 10.1016/j.neurobiolaging.2018.01.015

Reeve, AK; Grady, JP; Cosgrave, EM; Bennison, E; Chen, C; Hepplewhite, PD; Morris, CM. (2018) Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson’s disease. NPJ PARKINSONS DISEASE, 10.1038/s41531-018-0044-6

Robinson, AC; McNamee, R; Davidson, YS; Horan, MA; Snowden, JS; Mclnnes, L; Pendleton, N; Mann, DMA. (2018) Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology.  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 10.1159/000486827

Taskesen, E; Mishra, A; van der Sluis, S; Ferrari, R; Veldink, JH; van Es, MA; Smit, AB; Posthuma, D; Pijnenburg, Y. (2018) Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS. SCIENTIFIC REPORTS, 10.1038/s41598-018-21308-x

Hadar, A; Milanesi, E; Walczak, M; Puzianowska-Kuznicka, M; Kuznicki, J; Squassina, A; Niola, P; Chillotti, C; Attems, J; Gozes, I; Gurwitz, D. (2018). SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease. SCIENTIFIC REPORTS, 10.1038/s41598-018-26547-6

Hainsworth, AH; Lee, S; Foot, P; Patel, A; Poon, WW; Knight, AE. (2018) Super-resolution imaging of subcortical white matter using stochastic optical reconstruction microscopy (STORM) and super-resolution optical fluctuation imaging (SOFI). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 10.1111/nan.12426